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<title>Annette Doherty</title>
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<span id="openzim-page-title" class="mw-page-title-main"><span class="mw-page-title-main">Annette Doherty</span></span>
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</style><table class="infobox biography vcard"><tbody><tr><th colspan="2" class="infobox-above" style="font-size:125%;"><div class="fn">Annette Marian Doherty</div><div class="honorific-suffix" style="font-size: 77%; font-weight: normal;"><span class="nobold noexcerpt nowraplinks" style="font-size:;"><span style="font-size: 85%;"><a href="Officer_of_the_Order_of_the_British_Empire" class="mw-redirect" title="Officer of the Order of the British Empire">OBE</a></span></span> <span class="nobold noexcerpt nowraplinks" style="font-size:;"><span style="font-size: 85%;"><a href="Fellow_of_the_Royal_Society_of_Chemistry" title="Fellow of the Royal Society of Chemistry">FRSC</a></span></span></div></th></tr><tr><th scope="row" class="infobox-label">Alma mater</th><td class="infobox-data"><a href="Imperial_College_London" title="Imperial College London">Imperial College London</a></td></tr><tr><td colspan="2" class="infobox-full-data"><b>Scientific career</b></td></tr><tr><th scope="row" class="infobox-label">Institutions</th><td class="infobox-data"><a href="Pfizer" title="Pfizer">Pfizer</a> <br> <a href="GSK_Plc" class="mw-redirect" title="GSK Plc">GSK Plc</a> <br> <a href="Ohio_State_University" title="Ohio State University">Ohio State University</a></td></tr><tr><th scope="row" class="infobox-label"><a href="Thesis" title="Thesis">Thesis</a></th><td class="infobox-data"><i><a rel="nofollow" class="external text" href="https://search.worldcat.org/en/title/1000621391">Synthetic approaches to ionophore antibiotics</a></i> <span style="font-size:97%;">(1985)</span></td></tr><tr style="display:none"><td colspan="2">
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<p><b>Annette Marian Doherty</b> is a British chemist who is President of the <a href="Royal_Society_of_Chemistry" title="Royal Society of Chemistry">Royal Society of Chemistry</a>. She was a leader in the pharmaceutical sector, where she focussed on new drugs for cancer and respiratory diseases. She has served as Chair of various NHS trusts and academies. She was appointed an <a href="Order_of_the_British_Empire" title="Order of the British Empire">Order of the British Empire</a> for services to the pharmaceutical sector in 2009.
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<div class="mw-heading mw-heading2"><h2 id="Early_life_and_education">Early life and education</h2></div>
<p>Doherty trained in chemistry at <a href="Imperial_College_London" title="Imperial College London">Imperial College London</a>.<sup id="cite_ref-:0_1-0" class="reference"><a href="#cite_note-:0-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-:1_2-0" class="reference"><a href="#cite_note-:1-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> She was at Imperial for undergraduate and graduate studies, before moving to <a href="Ohio_State_University" title="Ohio State University">Ohio State University</a> as a <a href="NATO" title="NATO">NATO</a> research fellow.<sup id="cite_ref-:2_3-0" class="reference"><a href="#cite_note-:2-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Her doctoral research investigated ionophore antibiotics.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup> She joined the <a href="Royal_Society_of_Chemistry" title="Royal Society of Chemistry">Royal Society of Chemistry</a> as a student, and has said that she understood the value it can add to people at all stages of their chemistry careers.<sup id="cite_ref-:3_5-0" class="reference"><a href="#cite_note-:3-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup>
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<div class="mw-heading mw-heading2"><h2 id="Career">Career</h2></div>
<p>Doherty spent thirty-five years in the <a href="Pharmaceutical_industry" title="Pharmaceutical industry">pharmaceutical industry</a>. She was interested in the development of new diseases for respiratory, infectious and inflammatory conditions, as well as many cancers. She worked at <a href="Warner%E2%80%93Lambert" title="Warner–Lambert">Warner–Lambert</a> and <a href="GSK_plc" title="GSK plc">GSK</a>. At [GSK, she was Head of Product Development and Clinical Supply. In 2012, she moved to <a href="Pfizer" title="Pfizer">Pfizer</a>, where she held similar leadership positions in drug development.<sup id="cite_ref-:4_6-0" class="reference"><a href="#cite_note-:4-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Doherty is a Senior Advisor at Frazier Life Sciences, who design and develop new therapeutics.<sup id="cite_ref-:1_2-1" class="reference"><a href="#cite_note-:1-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> In 2009, she was appointed an <a href="Order_of_the_British_Empire" title="Order of the British Empire">Order of the British Empire</a> for services to the pharmaceutical sector.<sup id="cite_ref-:2_3-1" class="reference"><a href="#cite_note-:2-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> She became a trustee of the <a href="Royal_Society_of_Chemistry" title="Royal Society of Chemistry">Royal Society of Chemistry</a> in 2011.<sup id="cite_ref-:3_5-1" class="reference"><a href="#cite_note-:3-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup>
</p><p>Alongside the design of new medicines, Doherty is passionate about health and quality of life. She joined the <a href="Cambridge_University_Hospitals_NHS_Foundation_Trust" title="Cambridge University Hospitals NHS Foundation Trust">Cambridge University Hospitals NHS Foundation Trust</a> in 2017, where she serves as <a href="Non-executive_director" title="Non-executive director">non-executive director</a>.<sup id="cite_ref-:0_1-1" class="reference"><a href="#cite_note-:0-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> She was made an Honorary Fellow of the <a href="British_Pharmacological_Society" title="British Pharmacological Society">British Pharmacological Society</a> in 2023.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> In May 2024 she was made Chair of <a href="Maidstone_and_Tunbridge_Wells_NHS_Trust" title="Maidstone and Tunbridge Wells NHS Trust">Maidstone and Tunbridge Wells NHS Trust</a>, where she spent one year before moving to <a href="East_Kent_Hospitals_University_NHS_Foundation_Trust" title="East Kent Hospitals University NHS Foundation Trust">East Kent Hospitals University NHS Foundation Trust</a>.<sup id="cite_ref-:0_1-2" class="reference"><a href="#cite_note-:0-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-10" class="reference"><a href="#cite_note-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup>
</p><p>Doherty was elected President of the <a href="Royal_Society_of_Chemistry" title="Royal Society of Chemistry">Royal Society of Chemistry</a> in 2024.<sup id="cite_ref-:4_6-1" class="reference"><a href="#cite_note-:4-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> She has said that she wants to improve participation and sense of belonging in chemistry, advocate for innovation and research, and focus chemists' effort on environmental sustainability.<sup id="cite_ref-:3_5-2" class="reference"><a href="#cite_note-:3-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup>
</p><p>Doherty is part of the <a href="Tonbridge_Grammar_School" title="Tonbridge Grammar School">Tonbridge Grammar School</a> Trust,<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> and serves on the council of <a href="Innovate_UK" title="Innovate UK">Innovate UK</a>.<sup id="cite_ref-:1_2-2" class="reference"><a href="#cite_note-:1-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>
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<div class="mw-heading mw-heading2"><h2 id="Selected_publications">Selected publications</h2></div>
<ul><li><style data-mw-deduplicate="TemplateStyles:r1238218222">
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</style><cite id="CITEREFWilliam_C._PattHarriet_W._HamiltonMichael_D._TaylorMichael_J._Ryan1992" class="citation journal cs1">William C. Patt; Harriet W. Hamilton; Michael D. Taylor; et al. (1 July 1992). <a rel="nofollow" class="external text" href="https://pubs.acs.org/doi/pdf/10.1021/jm00092a006">"Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors"</a>. <i><a href="Journal_of_Medicinal_Chemistry" title="Journal of Medicinal Chemistry">Journal of Medicinal Chemistry</a></i>. <b>35</b> (14): <span class="nowrap">2562–</span>2572. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1021%2FJM00092A006">10.1021/JM00092A006</a>. <a href="ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/0022-2623">0022-2623</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1635057">1635057</a>. <a href="WDQ_(identifier)" class="mw-redirect" title="WDQ (identifier)">Wikidata</a> <a href="https://www.wikidata.org/wiki/Q41970660" class="extiw external" title="d:Q41970660">Q41970660</a>.</cite></li>
<li><cite id="CITEREFDavid_W._FryAlexander_J._BridgesWilliam_A._DennyAnnette_Doherty1998" class="citation journal cs1">David W. Fry; Alexander J. Bridges; <a href="Bill_Denny_(medical_researcher)" title="Bill Denny (medical researcher)">William A. Denny</a>; et al. (29 September 1998). <a rel="nofollow" class="external text" href="https://europepmc.org/articles/pmc21758?pdf=render">"Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor"</a>. <i><a href="Proceedings_of_the_National_Academy_of_Sciences_of_the_United_States_of_America" title="Proceedings of the National Academy of Sciences of the United States of America">Proceedings of the National Academy of Sciences of the United States of America</a></i>. <b>95</b> (20): <span class="nowrap">12022–</span>7. <a href="Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1998PNAS...9512022F">1998PNAS...9512022F</a>. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1073%2FPNAS.95.20.12022">10.1073/PNAS.95.20.12022</a>. <a href="ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/0027-8424">0027-8424</a>. <a href="PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC21758">21758</a></span>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9751783">9751783</a>. <a href="WDQ_(identifier)" class="mw-redirect" title="WDQ (identifier)">Wikidata</a> <a href="https://www.wikidata.org/wiki/Q28368986" class="extiw external" title="d:Q28368986">Q28368986</a>.</cite></li>
<li><cite id="CITEREFStephen_D_BarrettAlexander_J_BridgesDavid_T_DudleyAlan_R_Saltiel2008" class="citation journal cs1">Stephen D Barrett; Alexander J Bridges; David T Dudley; et al. (15 October 2008). "The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901". <i><a href="Bioorganic_%26_Medicinal_Chemistry_Letters" title="Bioorganic & Medicinal Chemistry Letters">Bioorganic & Medicinal Chemistry Letters</a></i>. <b>18</b> (24): <span class="nowrap">6501–</span>6504. <a href="Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2FJ.BMCL.2008.10.054">10.1016/J.BMCL.2008.10.054</a>. <a href="ISSN_(identifier)" class="mw-redirect" title="ISSN (identifier)">ISSN</a> <a rel="nofollow" class="external text" href="https://search.worldcat.org/issn/0960-894X">0960-894X</a>. <a href="PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18952427">18952427</a>. <a href="WDQ_(identifier)" class="mw-redirect" title="WDQ (identifier)">Wikidata</a> <a href="https://www.wikidata.org/wiki/Q34014364" class="extiw external" title="d:Q34014364">Q34014364</a>.</cite></li></ul>
<div class="mw-heading mw-heading2"><h2 id="References">References</h2></div>
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